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The relationship between GLP-1 therapy and depression remains an active area of clinical investigation, with recent data suggesting the risk may vary based on individual biology and baseline mental health status

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Second, selenium is a core component of selenoproteins and a key regulator of thyroid hormone metabolism

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Although direct clinical evidence of systemic NAD(P) depletion during GLP-1RA therapy is lacking, experimental and observational studies suggest that NAD turnover and micronutrient status can be altered in obesity and inflammatory states [83, 85], supporting the biological plausibility of substrate-sensitive vulnerability

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